Minimax and admissible adaptive two-stage designs in phase II clinical trials

BACKGROUND: Simon’s two-stage design is the most widely implemented among multi-stage designs in phase II clinical trials to assess the activity of a new treatment in a single-arm study. In this two-stage design, the sample size from the second stage is fixed regardless of the number of responses ob...

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Detalles Bibliográficos
Autores principales: Shan, Guogen, Zhang, Hua, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969653/
https://www.ncbi.nlm.nih.gov/pubmed/27485595
http://dx.doi.org/10.1186/s12874-016-0194-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969653/
https://www.ncbi.nlm.nih.gov/pubmed/27485595
http://dx.doi.org/10.1186/s12874-016-0194-3

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