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The importance of serine metabolism in cancer
Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase serine synthesis from glucose and require...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970329/ https://www.ncbi.nlm.nih.gov/pubmed/27458133 http://dx.doi.org/10.1083/jcb.201604085 |
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author | Mattaini, Katherine R. Sullivan, Mark R. Vander Heiden, Matthew G. |
author_facet | Mattaini, Katherine R. Sullivan, Mark R. Vander Heiden, Matthew G. |
author_sort | Mattaini, Katherine R. |
collection | PubMed |
description | Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase serine synthesis from glucose and require de novo serine synthesis even in the presence of abundant extracellular serine. Recent studies cast new light on the role of serine metabolism in cancer, suggesting that active serine synthesis might be required to facilitate amino acid transport, nucleotide synthesis, folate metabolism, and redox homeostasis in a manner that impacts cancer. |
format | Online Article Text |
id | pubmed-4970329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49703292017-02-01 The importance of serine metabolism in cancer Mattaini, Katherine R. Sullivan, Mark R. Vander Heiden, Matthew G. J Cell Biol Reviews Serine metabolism is frequently dysregulated in cancers; however, the benefit that this confers to tumors remains controversial. In many cases, extracellular serine alone is sufficient to support cancer cell proliferation, whereas some cancer cells increase serine synthesis from glucose and require de novo serine synthesis even in the presence of abundant extracellular serine. Recent studies cast new light on the role of serine metabolism in cancer, suggesting that active serine synthesis might be required to facilitate amino acid transport, nucleotide synthesis, folate metabolism, and redox homeostasis in a manner that impacts cancer. The Rockefeller University Press 2016-08-01 /pmc/articles/PMC4970329/ /pubmed/27458133 http://dx.doi.org/10.1083/jcb.201604085 Text en © 2016 Mattaini et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Reviews Mattaini, Katherine R. Sullivan, Mark R. Vander Heiden, Matthew G. The importance of serine metabolism in cancer |
title | The importance of serine metabolism in cancer |
title_full | The importance of serine metabolism in cancer |
title_fullStr | The importance of serine metabolism in cancer |
title_full_unstemmed | The importance of serine metabolism in cancer |
title_short | The importance of serine metabolism in cancer |
title_sort | importance of serine metabolism in cancer |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970329/ https://www.ncbi.nlm.nih.gov/pubmed/27458133 http://dx.doi.org/10.1083/jcb.201604085 |
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