Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity

In canonical Wnt signaling, the protein levels of the key signaling mediator β-catenin are under tight regulation by the multimeric destruction complex that mediates proteasomal degradation of β-catenin. In colorectal cancer, destruction complex activity is often compromised due to mutations in the...

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Detalles Bibliográficos
Autores principales: Pedersen, Nina Marie, Thorvaldsen, Tor Espen, Schultz, Sebastian Wolfgang, Wenzel, Eva Maria, Stenmark, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970726/
https://www.ncbi.nlm.nih.gov/pubmed/27482906
http://dx.doi.org/10.1371/journal.pone.0160507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970726/
https://www.ncbi.nlm.nih.gov/pubmed/27482906
http://dx.doi.org/10.1371/journal.pone.0160507

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