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Formation of Tankyrase Inhibitor-Induced Degradasomes Requires Proteasome Activity
In canonical Wnt signaling, the protein levels of the key signaling mediator β-catenin are under tight regulation by the multimeric destruction complex that mediates proteasomal degradation of β-catenin. In colorectal cancer, destruction complex activity is often compromised due to mutations in the...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970726/ https://www.ncbi.nlm.nih.gov/pubmed/27482906 http://dx.doi.org/10.1371/journal.pone.0160507 |