Deep Sequencing Reveals Novel Genetic Variants in Children with Acute Liver Failure and Tissue Evidence of Impaired Energy Metabolism

BACKGROUND & AIMS: The etiology of acute liver failure (ALF) remains elusive in almost half of affected children. We hypothesized that inherited mitochondrial and fatty acid oxidation disorders were occult etiological factors in patients with idiopathic ALF and impaired energy metabolism. METHOD...

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Detalles Bibliográficos
Autores principales: Valencia, C. Alexander, Wang, Xinjian, Wang, Jin, Peters, Anna, Simmons, Julia R., Moran, Molly C., Mathur, Abhinav, Husami, Ammar, Qian, Yaping, Sheridan, Rachel, Bove, Kevin E., Witte, David, Huang, Taosheng, Miethke, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970743/
https://www.ncbi.nlm.nih.gov/pubmed/27483465
http://dx.doi.org/10.1371/journal.pone.0156738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970743/
https://www.ncbi.nlm.nih.gov/pubmed/27483465
http://dx.doi.org/10.1371/journal.pone.0156738

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