Development of DS‐5573a: A novel afucosylated mAb directed at B7‐H3 with potent antitumor activity

B7‐H3 is highly overexpressed in a variety of human clinical tumors, and its expression is significantly associated with poor outcomes. In our study, we aimed to develop new antitumor mAbs by employing cancer cell immunization, and succeeded in generating a mouse anti‐human B7‐H3 antibody (M30) that...

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Detalles Bibliográficos
Autores principales: Nagase‐Zembutsu, Akiko, Hirotani, Kenji, Yamato, Michiko, Yamaguchi, Junko, Takata, Takehiko, Yoshida, Makoto, Fukuchi, Keisuke, Yazawa, Mitsuhiro, Takahashi, Shu, Agatsuma, Toshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970835/
https://www.ncbi.nlm.nih.gov/pubmed/26914241
http://dx.doi.org/10.1111/cas.12915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970835/
https://www.ncbi.nlm.nih.gov/pubmed/26914241
http://dx.doi.org/10.1111/cas.12915

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