Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations

CONTEXT: The pathogenic effect of mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene (AIPmuts) in pituitary adenomas is incompletely understood. We have identified the primary mechanism of loss of function for missense AIPmuts. OBJECTIVE: This study sought to analyze the mecha...

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Detalles Bibliográficos
Autores principales: Hernández-Ramírez, Laura C., Martucci, Federico, Morgan, Rhodri M. L., Trivellin, Giampaolo, Tilley, Daniel, Ramos-Guajardo, Nancy, Iacovazzo, Donato, D'Acquisto, Fulvio, Prodromou, Chrisostomos, Korbonits, Márta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971335/
https://www.ncbi.nlm.nih.gov/pubmed/27253664
http://dx.doi.org/10.1210/jc.2016-1307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971335/
https://www.ncbi.nlm.nih.gov/pubmed/27253664
http://dx.doi.org/10.1210/jc.2016-1307

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