Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha

Nonalcoholic fatty liver disease (NAFLD/steatosis) is a metabolic disease characterized by the incorporation of fat into hepatocytes. In this study, we developed an in vitro model for NAFLD based on hepatocyte-like cells (HLCs) differentiated from human pluripotent stem cells. We induced fat storage...

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Detalles Bibliográficos
Autores principales: Graffmann, Nina, Ring, Sarah, Kawala, Marie-Ann, Wruck, Wasco, Ncube, Audrey, Trompeter, Hans-Ingo, Adjaye, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2016
Materias:
Original Research Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971413/
https://www.ncbi.nlm.nih.gov/pubmed/27308945
http://dx.doi.org/10.1089/scd.2015.0383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971413/
https://www.ncbi.nlm.nih.gov/pubmed/27308945
http://dx.doi.org/10.1089/scd.2015.0383

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