Cargando…

Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha

Nonalcoholic fatty liver disease (NAFLD/steatosis) is a metabolic disease characterized by the incorporation of fat into hepatocytes. In this study, we developed an in vitro model for NAFLD based on hepatocyte-like cells (HLCs) differentiated from human pluripotent stem cells. We induced fat storage...

Descripción completa

Detalles Bibliográficos
Autores principales:	Graffmann, Nina, Ring, Sarah, Kawala, Marie-Ann, Wruck, Wasco, Ncube, Audrey, Trompeter, Hans-Ingo, Adjaye, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2016
Materias:	Original Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971413/ https://www.ncbi.nlm.nih.gov/pubmed/27308945 http://dx.doi.org/10.1089/scd.2015.0383

Ejemplares similares

Cell fate decisions of human iPSC-derived bipotential hepatoblasts depend on cell density
por: Graffmann, Nina, et al.
Publicado: (2018)

Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Acquire Rejuvenation and Reduced Heterogeneity
por: Wruck, Wasco, et al.
Publicado: (2021)

The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells
por: Nguyen, Lisa, et al.
Publicado: (2022)

Correction: Nguyen et al. The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells. Cells 2022, 11, 635
por: Nguyen, Lisa, et al.
Publicado: (2022)

Human pluripotent stem cell derived HLC transcriptome data enables molecular dissection of hepatogenesis
por: Wruck, Wasco, et al.
Publicado: (2018)

Transcriptomic analysis of marine endophytic fungi extract identifies highly enriched anti-fungal fractions targeting cancer pathways in HepG2 cell lines
por: Blessie, Ethel Juliet, et al.
Publicado: (2020)

Meta-analysis of human prefrontal cortex reveals activation of GFAP and decline of synaptic transmission in the aging brain
por: Wruck, Wasco, et al.
Publicado: (2020)

Free Bilirubin Induces Neuro-Inflammation in an Induced Pluripotent Stem Cell-Derived Cortical Organoid Model of Crigler-Najjar Syndrome
por: Pranty, Abida Islam, et al.
Publicado: (2023)

miR-27 Negatively Regulates Pluripotency-Associated Genes in Human Embryonal Carcinoma Cells
por: Fuchs, Heiko, et al.
Publicado: (2014)

A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference
por: Graffmann, Nina, et al.
Publicado: (2021)

The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2(+) Urine Derived Renal Progenitor Cells
por: Rahman, Md Shaifur, et al.
Publicado: (2020)

The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time
por: Rahman, Md Shaifur, et al.
Publicado: (2018)

Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease
por: Wruck, Wasco, et al.
Publicado: (2017)

SARS-CoV-2 receptor ACE2 is co-expressed with genes related to transmembrane serine proteases, viral entry, immunity and cellular stress
por: Wruck, Wasco, et al.
Publicado: (2020)

Detailed phylogenetic analysis tracks transmission of distinct SARS-COV-2 variants from China and Europe to West Africa
por: Wruck, Wasco, et al.
Publicado: (2021)

Transcriptome-based analysis of blood samples reveals elevation of DNA damage response, neutrophil degranulation, cancer and neurodegenerative pathways in Plasmodium falciparum patients
por: Karikari, Akua A., et al.
Publicado: (2021)

Functional omics analyses reveal only minor effects of microRNAs on human somatic stem cell differentiation
por: Schira-Heinen, Jessica, et al.
Publicado: (2020)

Activation of the Renin–Angiotensin System Disrupts the Cytoskeletal Architecture of Human Urine-Derived Podocytes
por: Erichsen, Lars, et al.
Publicado: (2022)

Natural Products in Renal-Associated Drug Discovery
por: Wruck, Wasco, et al.
Publicado: (2023)

Unveiling Angiotensin II and Losartan-Induced Gene Regulatory Networks Using Human Urine-Derived Podocytes
por: Thimm, Chantelle, et al.
Publicado: (2023)

Gene expression studies of WT1 mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early kidney stem cell origin
por: Royer-Pokora, Brigitte, et al.
Publicado: (2023)

Combined sequencing of mRNA and DNA from human embryonic stem cells
por: Mertes, Florian, et al.
Publicado: (2016)

Nijmegen Breakage Syndrome fibroblasts and iPSCs: cellular models for uncovering disease-associated signaling pathways and establishing a screening platform for anti-oxidants
por: Mlody, Barbara, et al.
Publicado: (2017)

Derivation of the Immortalized Cell Line UM51-PrePodo-hTERT and Its Responsiveness to Angiotensin II and Activation of the RAAS Pathway
por: Erichsen, Lars, et al.
Publicado: (2023)

Footprint-free human fetal foreskin derived iPSCs: A tool for modeling hepatogenesis associated gene regulatory networks
por: Matz, Peggy, et al.
Publicado: (2017)

Characterisation of human induced pluripotent stem cell-derived hepatocyte-like cells and endodermal progenitors
por: Matz, Peggy, et al.
Publicado: (2014)

Editorial for Special Issue: iPS Cells (iPSCs) for Modelling and Treatment of Human Diseases
por: Graffmann, Nina, et al.
Publicado: (2022)

JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis
por: Nguyen, Lisa, et al.
Publicado: (2023)

Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally
por: Du, Jin, et al.
Publicado: (2019)

Correspondence: Confirmation of Uterotrophic Activity for 4-MBC in the Immature Rat
por: Ashby, J
Publicado: (2001)

Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer’s disease donor as a model for investigating AD-associated gene regulatory networks
por: Hossini, Amir M, et al.
Publicado: (2015)

Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease
por: Wang, Nan, et al.
Publicado: (2017)

Erratum: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks
por: Hossini, Amir M, et al.
Publicado: (2015)

PLIN1 Haploinsufficiency Is Not Associated With Lipodystrophy
por: Laver, Thomas W, et al.
Publicado: (2018)

Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat.
por: Tinwell, Helen, et al.
Publicado: (2002)

FGF Signalling in the Self-Renewal of Colon Cancer Organoids
por: Otte, Jörg, et al.
Publicado: (2019)

Skeletal muscle PLIN3 and PLIN5 are serine phosphorylated at rest and following lipolysis during adrenergic or contractile stimulation
por: MacPherson, Rebecca E K, et al.
Publicado: (2013)

Isolation and Molecular Characterization of Amniotic Fluid-Derived Mesenchymal Stem Cells Obtained from Caesarean Sections
por: Spitzhorn, Lucas-Sebastian, et al.
Publicado: (2017)

Combined ultra-low input mRNA and whole-genome sequencing of human embryonic stem cells
por: Mertes, Florian, et al.
Publicado: (2015)

Urine-Based Detection of Biomarkers Indicative of Chronic Kidney Disease in a Patient Cohort from Ghana
por: Wruck, Wasco, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_37kn07jlngratir2k8rj7dlpm1