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p18 inhibits reprogramming through inactivation of Cdk4/6

Pluripotent stem cells (PSCs), including embryonic and induced pluripotent stem cells (iPSCs), show atypical cell cycle regulation characterized by a high proliferation rate and a shorter G1 phase compared with somatic cells. The mechanisms by which somatic cells remodel their cell cycle to achieve...

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Detalles Bibliográficos
Autores principales: Zhu, Shaohua, Cao, Jiani, Sun, Hongyan, Liu, Kun, Li, Yaqiong, Zhao, Tongbiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971472/
https://www.ncbi.nlm.nih.gov/pubmed/27484146
http://dx.doi.org/10.1038/srep31085