Control of fibrotic changes through the synergistic effects of anti-fibronectin antibody and an RGDS-tagged form of the same antibody

TGF-β and myofibroblasts play a key role in fibrosis, characterized by aberrant synthesis and deposition of extracellular matrix (ECM) proteins, such as fibronectin (Fn) and collagen type I. There are two major roles played by integrins in the fibrotic pathology: (i) Fn-integrin interaction, coupled...

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Detalles Bibliográficos
Autores principales: Tiwari, Anil, Kumar, Rajendra, Ram, Jagat, Sharma, Maryada, Luthra-Guptasarma, Manni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971484/
https://www.ncbi.nlm.nih.gov/pubmed/27484779
http://dx.doi.org/10.1038/srep30872

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971484/
https://www.ncbi.nlm.nih.gov/pubmed/27484779
http://dx.doi.org/10.1038/srep30872

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