Interference in transcription of overexpressed genes by promoter-proximal downstream sequences

Despite a high sequence homology among four human RNAi-effectors Argonaute proteins and their coding sequences, the efficiency of ectopic overexpression of AGO3 and AGO4 coding sequences in human cells is greatly reduced as compared to AGO1 and AGO2. While investigating this phenomenon, we documente...

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Detalles Bibliográficos
Autores principales: Turchinovich, A., Surowy, H. M., Tonevitsky, A. G., Burwinkel, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971500/
https://www.ncbi.nlm.nih.gov/pubmed/27485701
http://dx.doi.org/10.1038/srep30735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971500/
https://www.ncbi.nlm.nih.gov/pubmed/27485701
http://dx.doi.org/10.1038/srep30735

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