Induction of Connective Tissue Growth Factor Expression by Hypoxia in Human Lung Fibroblasts via the MEKK1/MEK1/ERK1/GLI-1/GLI-2 and AP-1 Pathways

Several reports have indicated that hypoxia, GLI, and connective tissue growth factor (CTGF) contribute to pulmonary fibrosis in idiopathic pulmonary fibrosis. We investigated the participation of mitogen-activated protein kinase kinase (MEK) kinase 1 (MEKK1)/MEK1/ERK1/GLI-1/2 and activator protein-...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Yi, Lin, Chien-huang, Chen, Jing-Yun, Li, Chien-Hua, Liu, Yu-Tin, Chen, Bing-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972311/
https://www.ncbi.nlm.nih.gov/pubmed/27486656
http://dx.doi.org/10.1371/journal.pone.0160593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972311/
https://www.ncbi.nlm.nih.gov/pubmed/27486656
http://dx.doi.org/10.1371/journal.pone.0160593

Ejemplares similares