Cargando…

In Vitro Inhibition of NFAT5-Mediated Induction of CCL2 in Hyperosmotic Conditions by Cyclosporine and Dexamethasone on Human HeLa-Modified Conjunctiva-Derived Cells

PURPOSE: To investigate the pro-inflammatory intracellular mechanisms induced by an in vitro model of dry eye disease (DED) on a Hela-modified conjunctiva-derived cells in hyperosmolarity (HO) stress conditions. This study focused on CCL2 induction and explored the implications of the nuclear factor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Warcoin, Elise, Baudouin, Christophe, Gard, Carole, Brignole-Baudouin, Françoise
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972436/ https://www.ncbi.nlm.nih.gov/pubmed/27486749 http://dx.doi.org/10.1371/journal.pone.0159983

Ejemplares similares

Conjunctiva-Associated Lymphoid Tissue (CALT) Reactions to Antiglaucoma Prostaglandins with or without BAK-Preservative in Rabbit Acute Toxicity Study
por: Liang, Hong, et al.
Publicado: (2012)

Ocular safety of cationic emulsion of cyclosporine in an in vitro corneal wound-healing model and an acute in vivo rabbit model
por: Liang, Hong, et al.
Publicado: (2012)

Proinflammatory Markers, Chemokines, and Enkephalin in Patients Suffering from Dry Eye Disease
por: Nicolle, Pierre, et al.
Publicado: (2018)

Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: Involvement of NFAT5
por: Hollborn, Margrit, et al.
Publicado: (2015)

Toxicological evaluation of preservative-containing and preservative-free topical prostaglandin analogues on a three-dimensional-reconstituted corneal epithelium system
por: Liang, Hong, et al.
Publicado: (2011)

NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment
por: Yoshimoto, Shohei, et al.
Publicado: (2020)

Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay
por: Liang, Hong, et al.
Publicado: (2009)

The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells
por: Datta, Sandipan, et al.
Publicado: (2017)

Th1- and Th2-related chemokine and chemokine receptor expression on the ocular surface in endotoxin-induced uveitis
por: Trinh, Liem, et al.
Publicado: (2008)

Hyperosmolarity potentiates toxic effects of benzalkonium chloride on conjunctival epithelial cells in vitro
por: Clouzeau, Chloé, et al.
Publicado: (2012)

Effects of Benzalkonium Chloride on THP-1 Differentiated Macrophages In Vitro
por: Michée, Sylvain, et al.
Publicado: (2013)

The corneal endothelium in an endotoxin-induced uveitis model: correlation between in vivo confocal microscopy and immunohistochemistry
por: Trinh, Liem, et al.
Publicado: (2008)

HeLa-CCL2 cell heterogeneity studied by single-cell DNA and RNA sequencing
por: Hu, Wan-er, et al.
Publicado: (2019)

Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride
por: Liang, H, et al.
Publicado: (2008)

Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor
por: Dutot, Mélody, et al.
Publicado: (2008)

The Dual Effect of Rho-Kinase Inhibition on Trabecular Meshwork Cells Cytoskeleton and Extracellular Matrix in an In Vitro Model of Glaucoma
por: Buffault, Juliette, et al.
Publicado: (2022)

Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface
por: Akkurt Arslan, Murat, et al.
Publicado: (2023)

NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium
por: Ma, Pingping, et al.
Publicado: (2020)

Multiple endpoint analysis of BAC-preserved and unpreserved antiallergic eye drops on a 3D-reconstituted corneal epithelial model
por: Pauly, A., et al.
Publicado: (2011)

Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations
por: Akkurt Arslan, Murat, et al.
Publicado: (2021)

Comparative study on the cytotoxic effects of benzalkonium chloride on the Wong-Kilbourne derivative of Chang conjunctival and IOBA-NHC cell lines
por: Brasnu, E., et al.
Publicado: (2008)

Electrolyte Metabolism in HeLa Cells
por: Wickson-ginzburg, Margaret, et al.
Publicado: (1963)

Editorial: HeLa Cell Sequela
Publicado: (2013)

The fractured genome of HeLa cells
por: Mittelman, David, et al.
Publicado: (2013)

Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa
por: Shafi, Gowhar, et al.
Publicado: (2009)

Synergistic effects of Ferula gummosa and radiotherapy on induction of cytotoxicity in HeLa cell line
por: Forouzmand, Seyed Hamid, et al.
Publicado: (2018)

Comparison of Two Experimental Mouse Dry Eye Models through Inflammatory Gene Set Enrichment Analysis Based on a Multiplexed Transcriptomic Approach
por: Kessal, Karima, et al.
Publicado: (2021)

Single-walled carbon nanotube interactions with HeLa cells
por: Yehia, Hadi N, et al.
Publicado: (2007)

Conjunctival Inflammatory Gene Expression Profiling in Dry Eye Disease: Correlations With HLA-DRA and HLA-DRB1
por: Kessal, Karima, et al.
Publicado: (2018)

Lipid Annotation by Combination of UHPLC-HRMS (MS), Molecular Networking, and Retention Time Prediction: Application to a Lipidomic Study of In Vitro Models of Dry Eye Disease
por: Magny, Romain, et al.
Publicado: (2020)

FV peptide induces apoptosis in HEp 2 and HeLa cells: an insight into the mechanism of induction
por: Sri Balasubashini, M, et al.
Publicado: (2006)

High Induction of Poly(ADP‐ribose) Polymerase Activity in Bleomycin‐resistant HeLa Cells
por: Urade, Masahiro, et al.
Publicado: (1989)

Microtubule-associated proteins of HeLa cells: heat stability of the 200,000 mol wt HeLa MAPs and detection of the presence of MAP-2 in HeLa cell extracts and cycled microtubules
Publicado: (1982)

Nfat5 is involved in the hyperosmotic regulation of Tmem184b: a putative modulator of ibuprofen transport in renal MDCK I cells
por: Rasmussen, Rune Nørgaard, et al.
Publicado: (2019)

On the dynamics of the microfilament system in HeLa cells
por: Blikstad, I, et al.
Publicado: (1982)

Exploring the HeLa Dark Mitochondrial Proteome
por: Marini, Federica, et al.
Publicado: (2020)

Interleukin 10 Induces the Expression of Membrane-Bound HLA- G and the Production of Soluble HLA-G on HeLa CCL-2 Cells
por: Hasanah, Nurul, et al.
Publicado: (2019)

Evaluation of neuroprotective and immunomodulatory properties of mesenchymal stem cells in an ex vivo retinal explant model
por: Reboussin, Élodie, et al.
Publicado: (2022)

Regulatory mechanisms of fluvastatin and lovastatin for the p21 induction in human cervical cancer HeLa cells
por: Lin, Chi-Kang, et al.
Publicado: (2019)

Camellia japonica Root Extract Increases Antioxidant Genes by Induction of NRF2 in HeLa Cells
por: Kim, Jung-Hwan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_o2o6mfvd5bcd1m54lf4uluu1vu