Real-time imaging of Huntingtin aggregates diverting target search and gene transcription

The presumptive altered dynamics of transient molecular interactions in vivo contributing to neurodegenerative diseases have remained elusive. Here, using single-molecule localization microscopy, we show that disease-inducing Huntingtin (mHtt) protein fragments display three distinct dynamic states...

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Detalles Bibliográficos
Autores principales: Li, Li, Liu, Hui, Dong, Peng, Li, Dong, Legant, Wesley R, Grimm, Jonathan B, Lavis, Luke D, Betzig, Eric, Tjian, Robert, Liu, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972539/
https://www.ncbi.nlm.nih.gov/pubmed/27484239
http://dx.doi.org/10.7554/eLife.17056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972539/
https://www.ncbi.nlm.nih.gov/pubmed/27484239
http://dx.doi.org/10.7554/eLife.17056

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