Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis

PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole. Centriole engagement is known to block the reduplication of mother centrioles, but the molecu...

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Detalles Bibliográficos
Autores principales: Kim, Minhee, O'Rourke, Brian P., Soni, Rajesh Kumar, Jallepalli, Prasad V., Hendrickson, Ronald C., Tsou, Meng-Fu Bryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972634/
https://www.ncbi.nlm.nih.gov/pubmed/27425613
http://dx.doi.org/10.1016/j.celrep.2016.06.069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972634/
https://www.ncbi.nlm.nih.gov/pubmed/27425613
http://dx.doi.org/10.1016/j.celrep.2016.06.069

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