Neddylation requires glycyl-tRNA synthetase to protect activated E2

Neddylation is a post-translational modification that controls cell cycle and proliferation by conjugating the ubiquitin-like protein NEDD8 to specific targets. Here we report that glycyl-tRNA synthetase (GlyRS), an essential enzyme for protein synthesis, also plays a critical role in neddylation. I...

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Detalles Bibliográficos
Autores principales: Mo, Zhongying, Zhang, Qian, Liu, Ze, Lauer, Janelle, Shi, Yi, Sun, Litao, Griffin, Patrick R., Yang, Xiang-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972647/
https://www.ncbi.nlm.nih.gov/pubmed/27348078
http://dx.doi.org/10.1038/nsmb.3250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972647/
https://www.ncbi.nlm.nih.gov/pubmed/27348078
http://dx.doi.org/10.1038/nsmb.3250

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