Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis

The kynurenine pathway (KP) is the major metabolic pathway of the essential amino acid tryptophan (TRP). Stimulation by inflammatory molecules, such as interferon-γ (IFN-γ), is the trigger for induction of the KP, driving a complex cascade of production of both neuroprotective and neurotoxic metabol...

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Detalles Bibliográficos
Autores principales: Lovelace, Michael D., Varney, Bianca, Sundaram, Gayathri, Franco, Nunzio F., Ng, Mei Li, Pai, Saparna, Lim, Chai K., Guillemin, Gilles J., Brew, Bruce J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972824/
https://www.ncbi.nlm.nih.gov/pubmed/27540379
http://dx.doi.org/10.3389/fimmu.2016.00246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972824/
https://www.ncbi.nlm.nih.gov/pubmed/27540379
http://dx.doi.org/10.3389/fimmu.2016.00246

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