Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells

BACKGROUND: The role of anaplerotic nutrient entry into the Krebs cycle via pyruvate carboxylase has been the subject of increased scrutiny and in particular whether this is dysregulated in cancer. Here, we use a tracer-based NMR analysis involving high-resolution (1)H-(13)C-HSQC spectra to assess s...

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Detalles Bibliográficos
Autores principales: Reed, Michelle A. C., Ludwig, Christian, Bunce, Christopher M., Khanim, Farhat L., Günther, Ulrich L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972992/
https://www.ncbi.nlm.nih.gov/pubmed/27493727
http://dx.doi.org/10.1186/s40170-016-0155-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972992/
https://www.ncbi.nlm.nih.gov/pubmed/27493727
http://dx.doi.org/10.1186/s40170-016-0155-7

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