Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes

FasL-mediated cytotoxicity is one of the mechanisms that CTLs use to kill tumor cells. However, human colon carcinoma often deregulates the Fas signaling pathway to evade host cancer immune surveillance. We aimed at testing the hypothesis that novel ceramide analogs effectively modulate Fas function...

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Detalles Bibliográficos
Autores principales: Coe, Genevieve L., Redd, Priscilla S., Paschall, Amy V., Lu, Chunwan, Gu, Lilly, Cai, Houjian, Albers, Thomas, Lebedyeva, Iryna O., Liu, Kebin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973238/
https://www.ncbi.nlm.nih.gov/pubmed/27487939
http://dx.doi.org/10.1038/srep30816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973238/
https://www.ncbi.nlm.nih.gov/pubmed/27487939
http://dx.doi.org/10.1038/srep30816

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