Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway

Liver fibrosis is characterized by the activation of hepatic stellate cells (HSCs). Recent findings suggest that senescence of activated HSCs might limit the development of liver fibrosis. Based on previously observed anti-fibrotic effects of soluble egg antigens from Schistosoma japonicum in vitro,...

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Detalles Bibliográficos
Autores principales: Chen, Jinling, Pan, Jing, Wang, Jianxin, Song, Ke, Zhu, Dandan, Huang, Caiqun, Duan, Yinong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973244/
https://www.ncbi.nlm.nih.gov/pubmed/27489164
http://dx.doi.org/10.1038/srep30957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973244/
https://www.ncbi.nlm.nih.gov/pubmed/27489164
http://dx.doi.org/10.1038/srep30957

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