Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore

In mitochondrial apoptosis, Bak is activated by death signals to form pores of unknown structure on the mitochondrial outer membrane via homooligomerization. Cytochrome c and other apoptotic factors are released from the intermembrane space through these pores, initiating downstream apoptosis events...

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Detalles Bibliográficos
Autores principales: Mandal, Tirtha, Shin, Seungjin, Aluvila, Sreevidya, Chen, Hui-Chen, Grieve, Carter, Choe, Jun-Yong, Cheng, Emily H., Hustedt, Eric J., Oh, Kyoung Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973285/
https://www.ncbi.nlm.nih.gov/pubmed/27488021
http://dx.doi.org/10.1038/srep30763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973285/
https://www.ncbi.nlm.nih.gov/pubmed/27488021
http://dx.doi.org/10.1038/srep30763

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