Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase

High-frequency point mutations of genes encoding histones have been identified recently as novel drivers in a number of tumors. Specifically, the H3K36M/I mutations were shown to be oncogenic in chondroblastomas and undifferentiated sarcomas by inhibiting H3K36 methyltransferases, including SETD2. H...

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Detalles Bibliográficos
Autores principales: Yang, Shuang, Zheng, Xiangdong, Lu, Chao, Li, Guo-Min, Allis, C. David, Li, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973290/
https://www.ncbi.nlm.nih.gov/pubmed/27474439
http://dx.doi.org/10.1101/gad.284323.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973290/
https://www.ncbi.nlm.nih.gov/pubmed/27474439
http://dx.doi.org/10.1101/gad.284323.116

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