HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms

Hepatocyte nuclear factor 6 (HNF6) is required for liver development, but its role in adult liver metabolism is not known. Here we show that deletion of HNF6 in livers of adult C57Bl/6 mice leads to hepatic steatosis in mice fed normal laboratory chow. Although HNF6 is known mainly as a transcriptio...

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Detalles Bibliográficos
Autores principales: Zhang, Yuxiang, Fang, Bin, Damle, Manashree, Guan, Dongyin, Li, Zhenghui, Kim, Yong Hoon, Gannon, Maureen, Lazar, Mitchell A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973293/
https://www.ncbi.nlm.nih.gov/pubmed/27445394
http://dx.doi.org/10.1101/gad.281972.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973293/
https://www.ncbi.nlm.nih.gov/pubmed/27445394
http://dx.doi.org/10.1101/gad.281972.116

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