Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington’s Disease R6/1 Mice

Background: Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by CAG repeat expansions in the HTT gene. Somatic repeat expansion in the R6/1 mouse model of HD depends on mismatch repair and is worsened by base excision repair initiated by the 7,8-dihydroxy-8-oxoguanine-DNA...

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Detalles Bibliográficos
Autores principales: Møllersen, Linda, Moldestad, Olve, Rowe, Alexander D., Bjølgerud, Anja, Holm, Ingunn, Tveterås, Linda, Klungland, Arne, Retterstøl, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973517/
https://www.ncbi.nlm.nih.gov/pubmed/27540492
http://dx.doi.org/10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973517/
https://www.ncbi.nlm.nih.gov/pubmed/27540492
http://dx.doi.org/10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67

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