Targeting ASCT2‐mediated glutamine uptake blocks prostate cancer growth and tumour development

Glutamine is conditionally essential in cancer cells, being utilized as a carbon and nitrogen source for macromolecule production, as well as for anaplerotic reactions fuelling the tricarboxylic acid (TCA) cycle. In this study, we demonstrated that the glutamine transporter ASCT2 (SLC1A5) is highly...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Hardie, Rae‐Anne, Hoy, Andrew J, van Geldermalsen, Michelle, Gao, Dadi, Fazli, Ladan, Sadowski, Martin C, Balaban, Seher, Schreuder, Mark, Nagarajah, Rajini, Wong, Justin J‐L, Metierre, Cynthia, Pinello, Natalia, Otte, Nicholas J, Lehman, Melanie L, Gleave, Martin, Nelson, Colleen C, Bailey, Charles G, Ritchie, William, Rasko, John EJ, Holst, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973854/
https://www.ncbi.nlm.nih.gov/pubmed/25693838
http://dx.doi.org/10.1002/path.4518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973854/
https://www.ncbi.nlm.nih.gov/pubmed/25693838
http://dx.doi.org/10.1002/path.4518

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