Early Fungicidal Activity as a Candidate Surrogate Endpoint for All-Cause Mortality in Cryptococcal Meningitis: A Systematic Review of the Evidence

BACKGROUND: Cryptococcal meningitis (CM) is a leading cause of HIV-associated mortality. In clinical trials evaluating treatments for CM, biomarkers of early fungicidal activity (EFA) in cerebrospinal fluid (CSF) have been proposed as candidate surrogate endpoints for all- cause mortality (ACM). How...

Descripción completa

Detalles Bibliográficos
Autores principales: Montezuma-Rusca, Jairo M., Powers, John H., Follmann, Dean, Wang, Jing, Sullivan, Brigit, Williamson, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974008/
https://www.ncbi.nlm.nih.gov/pubmed/27490100
http://dx.doi.org/10.1371/journal.pone.0159727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974008/
https://www.ncbi.nlm.nih.gov/pubmed/27490100
http://dx.doi.org/10.1371/journal.pone.0159727

Ejemplares similares