Ribosome•RelA structures reveal the mechanism of stringent response activation

Stringent response is a conserved bacterial stress response underlying virulence and antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p)ppGpp, allowing bacteria to adapt to stress. RelA is activated during amino-acid starvation, when cognate deacyl-tRNA binds...

Descripción completa

Detalles Bibliográficos
Autores principales: Loveland, Anna B, Bah, Eugene, Madireddy, Rohini, Zhang, Ying, Brilot, Axel F, Grigorieff, Nikolaus, Korostelev, Andrei A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974054/
https://www.ncbi.nlm.nih.gov/pubmed/27434674
http://dx.doi.org/10.7554/eLife.17029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974054/
https://www.ncbi.nlm.nih.gov/pubmed/27434674
http://dx.doi.org/10.7554/eLife.17029

Ejemplares similares