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Ribosome•RelA structures reveal the mechanism of stringent response activation

Stringent response is a conserved bacterial stress response underlying virulence and antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p)ppGpp, allowing bacteria to adapt to stress. RelA is activated during amino-acid starvation, when cognate deacyl-tRNA binds...

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Detalles Bibliográficos
Autores principales:	Loveland, Anna B, Bah, Eugene, Madireddy, Rohini, Zhang, Ying, Brilot, Axel F, Grigorieff, Nikolaus, Korostelev, Andrei A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974054/ https://www.ncbi.nlm.nih.gov/pubmed/27434674 http://dx.doi.org/10.7554/eLife.17029

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