The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

Transient Receptor Potential Melastatin 2 (TRPM2) is a Ca(2+)-permeable cation channel essential for immunocyte activation, insulin secretion, and postischemic cell death. TRPM2 is activated by ADP ribose (ADPR) binding to its C-terminal cytosolic NUDT9-homology (NUDT9H) domain, homologous to the so...

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Detalles Bibliográficos
Autores principales: Iordanov, Iordan, Mihályi, Csaba, Tóth, Balázs, Csanády, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974056/
https://www.ncbi.nlm.nih.gov/pubmed/27383051
http://dx.doi.org/10.7554/eLife.17600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974056/
https://www.ncbi.nlm.nih.gov/pubmed/27383051
http://dx.doi.org/10.7554/eLife.17600

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