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An oxygen-regulated switch in the protein synthesis machinery

Protein synthesis involves the translation of ribonucleic acid information into proteins, the building blocks of life. The initial step of protein synthesis consists of the eukaryotic translation initiation factor 4E (eIF4E) binding to the 7-methylguanosine (m(7)-GpppG) 5′cap of mRNAs(1,2). Low oxyg...

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Detalles Bibliográficos
Autores principales: Uniacke, James, Holterman, Chet E., Lachance, Gabriel, Franovic, Aleksandra, Jacob, Mathieu D., Fabian, Marc R., Payette, Josianne, Holcik, Martin, Pause, Arnim, Lee, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974072/
https://www.ncbi.nlm.nih.gov/pubmed/22678294
http://dx.doi.org/10.1038/nature11055