Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

Cancer stem cells (CSCs) have key roles in treatment resistance, tumour metastasis and relapse. Using colorectal cancer (CC) cell lines, patient-derived xenograft (PDX) tissues and patient tissues, here we report that CC CSCs, which resist chemoradiation, have higher SUMO activating enzyme (E1) and...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Li, Li, Yi-Jia, Fakih, Marwan, Wiatrek, Rebecca L., Duldulao, Marjun, Chen, Zhenbin, Chu, Peiguo, Garcia-Aguilar, Julio, Chen, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974481/
https://www.ncbi.nlm.nih.gov/pubmed/27465491
http://dx.doi.org/10.1038/ncomms12326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974481/
https://www.ncbi.nlm.nih.gov/pubmed/27465491
http://dx.doi.org/10.1038/ncomms12326

Ejemplares similares