Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, representing approximately 75% of all renal neoplasms. ccRCC is known to be strongly associated with silencing of the von Hippel Lindau (VHL) tumor suppressor gene, yet VHL deficiency alone does not seem to be suffi...

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Detalles Bibliográficos
Autores principales: Johansson, Elinn, Rönö, Birgitte, Johansson, Martin, Lindgren, David, Möller, Christina, Axelson, Håkan, Smith, Emma M. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974510/
https://www.ncbi.nlm.nih.gov/pubmed/27491826
http://dx.doi.org/10.1038/srep30739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974510/
https://www.ncbi.nlm.nih.gov/pubmed/27491826
http://dx.doi.org/10.1038/srep30739

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