Cargando…

Molecular and Genetic Characterization of HIV-1 Tat Exon-1 Gene from Cameroon Shows Conserved Tat HLA-Binding Epitopes: Functional Implications

HIV-1 Tat plays a critical role in viral transactivation. Subtype-B Tat has potential use as a therapeutic vaccine. However, viral genetic diversity and population genetics would significantly impact the efficacy of such a vaccine. Over 70% of the 37-million HIV-infected individuals are in sub-Sahar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teto, Georges, Fonsah, Julius Y., Tagny, Claude T., Mbanya, Dora, Nchindap, Emilienne, Kenmogne, Leopoldine, Fokam, Joseph, Njamnshi, Dora M., Kouanfack, Charles, Njamnshi, Alfred K., Kanmogne, Georgette D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974531/ https://www.ncbi.nlm.nih.gov/pubmed/27438849 http://dx.doi.org/10.3390/v8070196

Ejemplares similares

Gag P2/NC and pol genetic diversity, polymorphism, and drug resistance mutations in HIV-1 CRF02_AG- and non-CRF02_AG-infected patients in Yaoundé, Cameroon
por: Teto, Georges, et al.
Publicado: (2017)

Adherence to Antiretroviral Therapy (ART) in Yaoundé-Cameroon: Association with Opportunistic Infections, Depression, ART Regimen and Side Effects
por: Fonsah, Julius Y., et al.
Publicado: (2017)

Variability in HIV-1 Integrase Gene and 3′-Polypurine Tract Sequences in Cameroon Clinical Isolates, and Implications for Integrase Inhibitors Efficacy
por: Acharya, Arpan, et al.
Publicado: (2020)

Effects of HIV on executive function and verbal fluency in Cameroon
por: Kanmogne, Georgette D., et al.
Publicado: (2018)

Depressive symptoms in HIV-infected and seronegative control subjects in Cameroon: Effect of age, education and gender
por: Kanmogne, Georgette D., et al.
Publicado: (2017)

Effects of HIV infection, antiretroviral therapy, and immune status on the speed of information processing and complex motor functions in adult Cameroonians
por: Kanmogne, Georgette D., et al.
Publicado: (2020)

HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon
por: Kanmogne, Georgette D, et al.
Publicado: (2010)

Hypertension in Cameroon associated with high likelihood of obstructive sleep apnea: a pilot study
por: Njamnshi, Alfred Kongnyu, et al.
Publicado: (2017)

Knowledge, attitude and seropositivity of hepatitis B virus among blood donors in the Bamenda Regional Hospital Blood Bank, Cameroon
por: Samje, Moses, et al.
Publicado: (2021)

Profile of blood cell abnormalities among antiretroviral therapy naïve HIV patients attending the Yaounde University Teaching Hospital, Cameroon
por: Wankah, Paul Nji, et al.
Publicado: (2014)

TatBC-Independent TatA/Tat Substrate Interactions Contribute to Transport Efficiency
por: Taubert, Johannes, et al.
Publicado: (2015)

HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells
por: Kukkonen, Sami, et al.
Publicado: (2014)

Risk Factors for Transmission of HIV in a Hospital Environment of Yaoundé, Cameroon
por: Mbanya, Dora, et al.
Publicado: (2010)

How to achieve Tat transport with alien TatA
por: Hauer, René Steffen, et al.
Publicado: (2017)

Epidemiology of epilepsy and relationship with onchocerciasis prevalence in villages of the Ntui Health District of Cameroon
por: Ngarka, Leonard, et al.
Publicado: (2023)

Substrate-triggered position switching of TatA and TatB during Tat transport in Escherichia coli
por: Habersetzer, Johann, et al.
Publicado: (2017)

Comparative Analysis of Tat-Dependent and Tat-Deficient Natural Lentiviruses
por: Bose, Deepanwita, et al.
Publicado: (2015)

TatA and TatB generate a hydrophobic mismatch important for the function and assembly of the Tat translocon in Escherichia coli
por: Mehner-Breitfeld, Denise, et al.
Publicado: (2022)

The Burden of Orphans and Vulnerable Children Due to HIV/AIDS in Cameroon
por: Nsagha, Dickson S, et al.
Publicado: (2012)

Characterization of a TatA/TatB binding site on the TatC component of the Escherichia coli twin arginine translocase
por: Severi, Emmanuele, et al.
Publicado: (2023)

Prevalence of anti-hepatitis C antibodies and its co-infection with HIV in rural Cameroon
por: Agbor, Valirie Ndip, et al.
Publicado: (2018)

A reversal of Tat
por: Tuma, Rabiya S.
Publicado: (2005)

The two sides of Tat
por: Barboric, Matjaz, et al.
Publicado: (2016)

TatB Functions as an Oligomeric Binding Site for Folded Tat Precursor Proteins
por: Maurer, Carlo, et al.
Publicado: (2010)

Mechanism of HIV-1 Tat RNA translation and its activation by the Tat protein
por: Charnay, Nicolas, et al.
Publicado: (2009)

Molecular dissection of TatC defines critical regions essential for protein transport and a TatB–TatC contact site
por: Kneuper, Holger, et al.
Publicado: (2012)

TatBC, TatB, and TatC form structurally autonomous units within the twin arginine protein transport system of Escherichia coli
por: Orriss, George L., et al.
Publicado: (2007)

Effect on HIV-1 Gene Expression, Tat-Vpr Interaction and Cell Apoptosis by Natural Variants of HIV-1 Tat Exon 1 and Vpr from Northern India
por: Lata, Sneh, et al.
Publicado: (2013)

Unanticipated functional diversity among the TatA-type components of the Tat protein translocase
por: Eimer, Ekaterina, et al.
Publicado: (2018)

New insights into the Tat protein transport cycle from characterizing the assembled Tat translocon
por: Alcock, Felicity, et al.
Publicado: (2022)

Lipid Peroxidation and Total Cholesterol in HAART-Naïve Patients Infected with Circulating Recombinant Forms of Human Immunodeficiency Virus Type-1 in Cameroon
por: Teto, Georges, et al.
Publicado: (2013)

Genetic Evidence for a Tight Cooperation of TatB and TatC during Productive Recognition of Twin-Arginine (Tat) Signal Peptides in Escherichia coli
por: Lausberg, Frank, et al.
Publicado: (2012)

Tat substrates open the portal
por: Short, Ben
Publicado: (2014)

Sec and Tat share the workload
por: Short, Ben
Publicado: (2012)

Assembling the Tat protein translocase
por: Alcock, Felicity, et al.
Publicado: (2016)

The Tat and Cat in Clinical Use
por: Franks, Cyril M.
Publicado: (1955)

From ESMO TAT 2021
por: Killock, David
Publicado: (2021)

Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat
por: Egelé, Caroline, et al.
Publicado: (2008)

Dynamic interactions of the HIV-1 Tat with nucleic acids are critical for Tat activity in reverse transcription
por: Boudier, Christian, et al.
Publicado: (2014)

Twin-Arginine Translocation System in Helicobacter pylori: TatC, but Not TatB, Is Essential for Viability
por: Benoit, Stéphane L., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_4c5v6ev1bvgq2toidj6cd3pfqd