PKM2 enhances chemosensitivity to cisplatin through interaction with the mTOR pathway in cervical cancer

Pyruvate kinase M2 (PKM2) is a key driver of aerobic glycolysis in cancer cells and has been shown to be up-regulated by mTOR in vitro. Our previous proteomic profiling studies showed that PKM2 was significantly upregulated in cervical cancer tissues after treatment with neoadjuvant chemotherapy (NA...

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Detalles Bibliográficos
Autores principales: Zhu, Haiyan, Wu, Jun, Zhang, Wenwen, Luo, Hui, Shen, Zhaojun, Cheng, Huihui, Zhu, Xueqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974606/
https://www.ncbi.nlm.nih.gov/pubmed/27492148
http://dx.doi.org/10.1038/srep30788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974606/
https://www.ncbi.nlm.nih.gov/pubmed/27492148
http://dx.doi.org/10.1038/srep30788

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