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PKM2 enhances chemosensitivity to cisplatin through interaction with the mTOR pathway in cervical cancer
Pyruvate kinase M2 (PKM2) is a key driver of aerobic glycolysis in cancer cells and has been shown to be up-regulated by mTOR in vitro. Our previous proteomic profiling studies showed that PKM2 was significantly upregulated in cervical cancer tissues after treatment with neoadjuvant chemotherapy (NA...
Autores principales: | Zhu, Haiyan, Wu, Jun, Zhang, Wenwen, Luo, Hui, Shen, Zhaojun, Cheng, Huihui, Zhu, Xueqiong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974606/ https://www.ncbi.nlm.nih.gov/pubmed/27492148 http://dx.doi.org/10.1038/srep30788 |
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