Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis

Targeted disruption of leukocyte trafficking to the gut represents a promising approach for the treatment of inflammatory bowel diseases (IBDs). CCR5, the shared receptor for MIP1α and β and RANTES, is expressed by multiple leukocytes. Here, we aimed to determine the role of CCR5 in mediating leukoc...

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Detalles Bibliográficos
Autores principales: Mencarelli, Andrea, Cipriani, Sabrina, Francisci, Daniela, Santucci, Luca, Baldelli, Franco, Distrutti, Eleonora, Fiorucci, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974621/
https://www.ncbi.nlm.nih.gov/pubmed/27492684
http://dx.doi.org/10.1038/srep30802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974621/
https://www.ncbi.nlm.nih.gov/pubmed/27492684
http://dx.doi.org/10.1038/srep30802

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