Cargando…

Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis

Targeted disruption of leukocyte trafficking to the gut represents a promising approach for the treatment of inflammatory bowel diseases (IBDs). CCR5, the shared receptor for MIP1α and β and RANTES, is expressed by multiple leukocytes. Here, we aimed to determine the role of CCR5 in mediating leukoc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mencarelli, Andrea, Cipriani, Sabrina, Francisci, Daniela, Santucci, Luca, Baldelli, Franco, Distrutti, Eleonora, Fiorucci, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974621/ https://www.ncbi.nlm.nih.gov/pubmed/27492684 http://dx.doi.org/10.1038/srep30802

Ejemplares similares

The Bile Acid Sensor FXR Protects against Dyslipidemia and Aortic Plaques Development Induced by the HIV Protease Inhibitor Ritonavir in Mice
por: Mencarelli, Andrea, et al.
Publicado: (2010)

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
por: Cipriani, Sabrina, et al.
Publicado: (2011)

Correction: The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
por: Cipriani, Sabrina, et al.
Publicado: (2013)

Probiotics VSL#3 Protect against Development of Visceral Pain in Murine Model of Irritable Bowel Syndrome
por: Distrutti, Eleonora, et al.
Publicado: (2013)

Nitric oxide protects against HIV gp120 endothelial injury
por: Fiorucci, S, et al.
Publicado: (2010)

Role of maraviroc in a dyslipidemic murine model of atherosclerosis RTV-induced
por: Cipriani, S, et al.
Publicado: (2012)

The HIV Matrix Protein p17 Subverts Nuclear Receptors Expression and Induces a STAT1-Dependent Proinflammatory Phenotype in Monocytes
por: Renga, Barbara, et al.
Publicado: (2012)

The Bile Acid Sensor FXR Is Required for Immune-Regulatory Activities of TLR-9 in Intestinal Inflammation
por: Renga, Barbara, et al.
Publicado: (2013)

Hydrogen sulphide induces μ opioid receptor-dependent analgesia in a rodent model of visceral pain
por: Distrutti, Eleonora, et al.
Publicado: (2010)

The HIV matrix protein p17 induces hepatic lipid accumulation via modulation of nuclear receptor transcriptoma
por: Renga, Barbara, et al.
Publicado: (2015)

VSL#3 Resets Insulin Signaling and Protects against NASH and Atherosclerosis in a Model of Genetic Dyslipidemia and Intestinal Inflammation
por: Mencarelli, Andrea, et al.
Publicado: (2012)

Probiotics Modulate Intestinal Expression of Nuclear Receptor and Provide Counter-Regulatory Signals to Inflammation-Driven Adipose Tissue Activation
por: Mencarelli, Andrea, et al.
Publicado: (2011)

Decoding the role of the nuclear receptor SHP in regulating hepatic stellate cells and liver fibrogenesis
por: Cipriani, Sabrina, et al.
Publicado: (2017)

Dissociation of Intestinal and Hepatic Activities of FXR and LXRα Supports Metabolic Effects of Terminal Ileum Interposition in Rodents
por: Mencarelli, Andrea, et al.
Publicado: (2013)

Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis
por: Mencarelli, Andrea, et al.
Publicado: (2013)

Bile Acids Activated Receptors in Inflammatory Bowel Disease
por: Biagioli, Michele, et al.
Publicado: (2021)

Bile Acid Signaling in Inflammatory Bowel Diseases
por: Fiorucci, Stefano, et al.
Publicado: (2020)

Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP
por: Distrutti, Eleonora, et al.
Publicado: (2014)

Bile Acids Activated Receptors Regulate Innate Immunity
por: Fiorucci, Stefano, et al.
Publicado: (2018)

HIV-1 infection is associated with changes in nuclear receptor transcriptome, pro-inflammatory and lipid profile of monocytes
por: Renga, Barbara, et al.
Publicado: (2012)

Metabolic Variability of a Multispecies Probiotic Preparation Impacts on the Anti-inflammatory Activity
por: Biagioli, Michele, et al.
Publicado: (2017)

The HIV Matrix Protein p17 Promotes the Activation of Human Hepatic Stellate Cells through Interactions with CXCR2 and Syndecan-2
por: Renga, Barbara, et al.
Publicado: (2014)

Leukocyte Trafficking and Regulation of Murine Hematopoietic Stem Cells and Their Niches
por: Lucas, Daniel
Publicado: (2019)

Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission
por: Chang, Xiao L., et al.
Publicado: (2021)

Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection
por: Glass, William G., et al.
Publicado: (2005)

Lack of protective effect of CCR3 blockade during experimental colitis may be related to CCR3 expression by colonic Tregs
por: Ferhat, Maroua, et al.
Publicado: (2021)

Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties
por: Biagioli, Michele, et al.
Publicado: (2019)

FXR an emerging therapeutic target for the treatment of atherosclerosis
por: Mencarelli, Andrea, et al.
Publicado: (2010)

The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines
por: Carino, Adriana, et al.
Publicado: (2016)

Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain
por: Carino, Adriana, et al.
Publicado: (2020)

Why CCR2 and CCR5 Blockade Failed and Why CCR1 Blockade Might Still Be Effective in the Treatment of Rheumatoid Arthritis
por: Lebre, Maria C., et al.
Publicado: (2011)

Blockade of adenosine A(2B) receptors ameliorates murine colitis
por: Kolachala, V L, et al.
Publicado: (2008)

CCR7-dependent trafficking of RORγ(+) ILCs creates a unique microenvironment within mucosal draining lymph nodes
por: Mackley, Emma C., et al.
Publicado: (2015)

The Expanding Therapeutic Perspective of CCR5 Blockade
por: Vangelista, Luca, et al.
Publicado: (2018)

Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases
por: Festa, Carmen, et al.
Publicado: (2017)

Leukocyte trafficking in alveoli and airway passages
por: Doerschuk, Claire M
Publicado: (2000)

Imaging of Leukocyte Trafficking in Alzheimer’s Disease
por: Pietronigro, Enrica, et al.
Publicado: (2016)

Editorial: Leukocyte Trafficking in Homeostasis and Disease
por: Teixidó, Joaquin, et al.
Publicado: (2019)

Vascular Endothelial Galectins in Leukocyte Trafficking
por: Lightfoot, Abbey, et al.
Publicado: (2021)

Corrigendum: CCR7-dependent trafficking of RORγ(+) ILCs creates a unique microenvironment within mucosal draining lymph nodes
por: Mackley, Emma C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_t3cl7s9fu03t1qmdflvs9su1k3