Cargando…

A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells

BACKGROUND: Radioresistant glioblastoma stem cells (GSCs) contribute to tumor recurrence and identification of the molecular targets involved in radioresistance mechanisms is likely to enhance therapeutic efficacy. This study analyzed the DNA damage response following ionizing radiation (IR) in 10 G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Balbous, Anaïs, Cortes, Ulrich, Guilloteau, Karline, Rivet, Pierre, Pinel, Baptiste, Duchesne, Mathilde, Godet, Julie, Boissonnade, Odile, Wager, Michel, Bensadoun, René Jean, Chomel, Jean-Claude, Karayan-Tapon, Lucie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974671/ https://www.ncbi.nlm.nih.gov/pubmed/27495836 http://dx.doi.org/10.1186/s12885-016-2647-9

Ejemplares similares

Cell Cycle Changes after Glioblastoma Stem Cell Irradiation: The Major Role of RAD51
por: Tachon, Gaelle, et al.
Publicado: (2018)

Impact of STAT3 phosphorylation in glioblastoma stem cells radiosensitization and patient outcome
por: Masliantsev, Konstantin, et al.
Publicado: (2017)

Crizotinib targets in glioblastoma stem cells
por: Junca, Audelaure, et al.
Publicado: (2017)

A mesenchymal glioma stem cell profile is related to clinical outcome
por: Balbous, A, et al.
Publicado: (2014)

EGFR, KRAS, BRAF, and HER-2 molecular status in brain metastases from 77 NSCLC patients
por: Villalva, Claire, et al.
Publicado: (2013)

IL22/IL-22R Pathway Induces Cell Survival in Human Glioblastoma Cells
por: Akil, Hussein, et al.
Publicado: (2015)

Targeting NPM1 in irradiated cells inhibits NPM1 binding to RAD51, RAD51 foci formation and radiosensitizes NSCLC
por: Traver, Geri, et al.
Publicado: (2020)

O6-Methylguanine-Methyltransferase (MGMT) Promoter Methylation Status in Glioma Stem-Like Cells is Correlated to Temozolomide Sensitivity Under Differentiation-Promoting Conditions
por: Villalva, Claire, et al.
Publicado: (2012)

RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells
por: King, Harry O., et al.
Publicado: (2017)

MEOX2 Transcription Factor Is Involved in Survival and Adhesion of Glioma Stem-like Cells
por: Tachon, Gaëlle, et al.
Publicado: (2021)

Dual MGMT inactivation by promoter hypermethylation and loss of the long arm of chromosome 10 in glioblastoma
por: Richard, Sophie, et al.
Publicado: (2020)

Roles of XRCC2, RAD51B and RAD51D in RAD51-Independent SSA Recombination
por: Serra, Heïdi, et al.
Publicado: (2013)

Functional invadopodia formed in glioblastoma stem cells are important regulators of tumor angiogenesis
por: Petropoulos, Christos, et al.
Publicado: (2018)

Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor
por: Greenhough, Luke A., et al.
Publicado: (2023)

Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51
por: Liu, Qiao, et al.
Publicado: (2011)

Homologous Pairing Activities of Two Rice RAD51 Proteins, RAD51A1 and RAD51A2
por: Morozumi, Yuichi, et al.
Publicado: (2013)

Pathological and Molecular Characteristics of Colorectal Cancer with Brain Metastases
por: Roussille, Pauline, et al.
Publicado: (2018)

Rad51 paralogs Rad55-Rad57 balance the anti-recombinase Srs2 in Rad51 filament formation
por: Liu, Jie, et al.
Publicado: (2011)

me101 is a new allele of rad-51
por: Roelens, Baptiste, et al.
Publicado: (2019)

Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction
por: Subramanyam, Shyamal, et al.
Publicado: (2013)

RAD51AP1 mediates RAD51 activity through nucleosome interaction
por: Pires, Elena, et al.
Publicado: (2021)

Hot on RAD51C: structure and functions of RAD51C‐XRCC3
por: Szakal, Barnabas, et al.
Publicado: (2023)

The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55–Rad57 to mediate error-free recombination
por: Godin, Stephen, et al.
Publicado: (2013)

Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination
por: Su, Hang, et al.
Publicado: (2017)

Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics
por: Li, Xuan, et al.
Publicado: (2007)

Rad51, friend or foe?
por: Tan-Wong, Sue Mei, et al.
Publicado: (2013)

RAD51 wrestles with SUMO
por: Kee, Younghoon, et al.
Publicado: (2022)

RAD51: Beyond the break
por: Wassing, Isabel E., et al.
Publicado: (2021)

Noncanonical Roles of RAD51
por: Thomas, Mélissa, et al.
Publicado: (2023)

RAD-ical New Insights into RAD51 Regulation
por: Sullivan, Meghan R., et al.
Publicado: (2018)

N(6)-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression
por: Navarra, Giovanna, et al.
Publicado: (2020)

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption
por: Colavito, Sierra, et al.
Publicado: (2009)

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination
por: Taylor, Martin R.G., et al.
Publicado: (2015)

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases
por: Guh, Chia-Lun, et al.
Publicado: (2023)

TODRA, a lncRNA at the RAD51 Locus, Is Oppositely Regulated to RAD51, and Enhances RAD51-Dependent DSB (Double Strand Break) Repair
por: Gazy, Inbal, et al.
Publicado: (2015)

Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation
por: Ma, Emilie, et al.
Publicado: (2018)

RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51
por: Kovalenko, Oleg V., et al.
Publicado: (2006)

A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling
por: Taylor, Martin R.G., et al.
Publicado: (2016)

Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D
por: Yang, Xin, et al.
Publicado: (2020)

Nucleotide proofreading functions by nematode RAD51 paralogs facilitate optimal RAD51 filament function
por: Špírek, Mário, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rc6vo95a3f5gc3ulq4nlk6dao2