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Will 1,2-dihydro-1,2-azaborine-based drugs resist metabolism by cytochrome P450 compound I?
1,2-dihydro-1,2-azaborine is a structural and electronic analogue of benzene which is able to occupy benzene-binding pockets in T4 lysozyme and has been proposed as suitable arene-mimicking group for biological and pharmaceutical applications. Its applicability in a biological context requires it to...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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PeerJ Inc.
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974919/ https://www.ncbi.nlm.nih.gov/pubmed/27547588 http://dx.doi.org/10.7717/peerj.2299 |