Eculizumab in the management of paroxysmal nocturnal hemoglobinuria: patient selection and special considerations

Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal disorder resulting from somatic mutation in the PIG-A gene leading to a deficiency of the membrane-anchoring molecule glycosylphosphatidylinositol. The lack of expression of two glycosylphosphatidylinositol-anchored proteins involved...

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Detalles Bibliográficos
Autores principales: Al-Ani, Fatimah, Chin-Yee, Ian, Lazo-Langner, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975135/
https://www.ncbi.nlm.nih.gov/pubmed/27536121
http://dx.doi.org/10.2147/TCRM.S96720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975135/
https://www.ncbi.nlm.nih.gov/pubmed/27536121
http://dx.doi.org/10.2147/TCRM.S96720

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