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Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2
We combined two tuberculosis (TB) genome-wide association studies (GWAS) from Ghana and The Gambia with subsequent replication totalling 11,425 participants. A significant association with disease was observed at SNP rs4331426 located in a gene-poor region on chromosome 18q11.2 (P=6.8×10(−9), OR=1.1...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975513/ https://www.ncbi.nlm.nih.gov/pubmed/20694014 http://dx.doi.org/10.1038/ng.639 |
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| author | Thye, Thorsten Vannberg, Fredrik O. Wong, Sunny H. Owusu-Dabo, Ellis Osei, Ivy Gyapong, John Sirugo, Giorgio Sisay-Joof, Fatou Enimil, Anthony Chinbuah, Margaret A. Floyd, Sian Warndorff, David K. Sichali, Lifted Malema, Simon Crampin, Amelia C. Ngwira, Bagrey Teo, Yik Y. Small, Kerrin Rockett, Kirk Kwiatkowski, Dominic Fine, Paul E. Hill, Philip C. Newport, Melanie Lienhardt, Christian Adegbola, Richard A. Corrah, Tumani Ziegler, Andreas Morris, Andrew P. Meyer, Christian G. Horstmann, Rolf D. Hill, Adrian V.S. |
| author_facet | Thye, Thorsten Vannberg, Fredrik O. Wong, Sunny H. Owusu-Dabo, Ellis Osei, Ivy Gyapong, John Sirugo, Giorgio Sisay-Joof, Fatou Enimil, Anthony Chinbuah, Margaret A. Floyd, Sian Warndorff, David K. Sichali, Lifted Malema, Simon Crampin, Amelia C. Ngwira, Bagrey Teo, Yik Y. Small, Kerrin Rockett, Kirk Kwiatkowski, Dominic Fine, Paul E. Hill, Philip C. Newport, Melanie Lienhardt, Christian Adegbola, Richard A. Corrah, Tumani Ziegler, Andreas Morris, Andrew P. Meyer, Christian G. Horstmann, Rolf D. Hill, Adrian V.S. |
| author_sort | Thye, Thorsten |
| collection | PubMed |
| description | We combined two tuberculosis (TB) genome-wide association studies (GWAS) from Ghana and The Gambia with subsequent replication totalling 11,425 participants. A significant association with disease was observed at SNP rs4331426 located in a gene-poor region on chromosome 18q11.2 (P=6.8×10(−9), OR=1.19, 95%CI=1.13-1.27). Our finding shows that GWAS can identify novel loci for infectious causes of mortality even in Africa where levels of linkage disequilibrium are particularly low. |
| format | Online Article Text |
| id | pubmed-4975513 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49755132016-08-05 Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 Thye, Thorsten Vannberg, Fredrik O. Wong, Sunny H. Owusu-Dabo, Ellis Osei, Ivy Gyapong, John Sirugo, Giorgio Sisay-Joof, Fatou Enimil, Anthony Chinbuah, Margaret A. Floyd, Sian Warndorff, David K. Sichali, Lifted Malema, Simon Crampin, Amelia C. Ngwira, Bagrey Teo, Yik Y. Small, Kerrin Rockett, Kirk Kwiatkowski, Dominic Fine, Paul E. Hill, Philip C. Newport, Melanie Lienhardt, Christian Adegbola, Richard A. Corrah, Tumani Ziegler, Andreas Morris, Andrew P. Meyer, Christian G. Horstmann, Rolf D. Hill, Adrian V.S. Nat Genet Article We combined two tuberculosis (TB) genome-wide association studies (GWAS) from Ghana and The Gambia with subsequent replication totalling 11,425 participants. A significant association with disease was observed at SNP rs4331426 located in a gene-poor region on chromosome 18q11.2 (P=6.8×10(−9), OR=1.19, 95%CI=1.13-1.27). Our finding shows that GWAS can identify novel loci for infectious causes of mortality even in Africa where levels of linkage disequilibrium are particularly low. 2010-08-08 2010-09 /pmc/articles/PMC4975513/ /pubmed/20694014 http://dx.doi.org/10.1038/ng.639 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Thye, Thorsten Vannberg, Fredrik O. Wong, Sunny H. Owusu-Dabo, Ellis Osei, Ivy Gyapong, John Sirugo, Giorgio Sisay-Joof, Fatou Enimil, Anthony Chinbuah, Margaret A. Floyd, Sian Warndorff, David K. Sichali, Lifted Malema, Simon Crampin, Amelia C. Ngwira, Bagrey Teo, Yik Y. Small, Kerrin Rockett, Kirk Kwiatkowski, Dominic Fine, Paul E. Hill, Philip C. Newport, Melanie Lienhardt, Christian Adegbola, Richard A. Corrah, Tumani Ziegler, Andreas Morris, Andrew P. Meyer, Christian G. Horstmann, Rolf D. Hill, Adrian V.S. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 |
| title | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 |
| title_full | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 |
| title_fullStr | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 |
| title_full_unstemmed | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 |
| title_short | Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 |
| title_sort | genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2 |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975513/ https://www.ncbi.nlm.nih.gov/pubmed/20694014 http://dx.doi.org/10.1038/ng.639 |
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