Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch

Cysteine string protein (CSP) is a member of the DnaJ/Hsp40 chaperone family that localizes to neuronal synaptic vesicles. Impaired CSP function leads to neurodegeneration in humans and model organisms as a result of misfolding of client proteins involved in neurotransmission. Mammalian CSP is phosp...

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Detalles Bibliográficos
Autores principales: Patel, Pryank, Prescott, Gerald R., Burgoyne, Robert D., Lian, Lu-Yun, Morgan, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975591/
https://www.ncbi.nlm.nih.gov/pubmed/27452402
http://dx.doi.org/10.1016/j.str.2016.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975591/
https://www.ncbi.nlm.nih.gov/pubmed/27452402
http://dx.doi.org/10.1016/j.str.2016.06.009

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