Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics

A molecular simulation pipeline for determining the mode of interaction of pleckstrin homology (PH) domains with phosphatidylinositol phosphate (PIP)-containing lipid bilayers is presented. We evaluate our methodology for the GRP1 PH domain via comparison with structural and biophysical data. Coarse...

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Detalles Bibliográficos
Autores principales: Yamamoto, Eiji, Kalli, Antreas C., Yasuoka, Kenji, Sansom, Mark S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Theory
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975593/
https://www.ncbi.nlm.nih.gov/pubmed/27427480
http://dx.doi.org/10.1016/j.str.2016.06.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975593/
https://www.ncbi.nlm.nih.gov/pubmed/27427480
http://dx.doi.org/10.1016/j.str.2016.06.002

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