Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model

We hypothesize that diabetes-induced impaired collateral formation after a hindlimb ligation in rats is in part caused by intracellular glycation and that overexpression of glyoxalase-I (GLO-I), i.e. the major detoxifying enzyme for advanced-glycation-endproduct (AGE) precursors, can prevent this. W...

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Detalles Bibliográficos
Autores principales: Brouwers, Olaf, Yu, Liang, Niessen, Petra, Slenter, Jos, Jaspers, Karolien, Wagenaar, Allard, Post, Mark, Miyata, Toshio, Backes, Walter, Stehouwer, Coen, Huijberts, Maya, Schalkwijk, Casper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975762/
https://www.ncbi.nlm.nih.gov/pubmed/27296676
http://dx.doi.org/10.1007/s10719-016-9681-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975762/
https://www.ncbi.nlm.nih.gov/pubmed/27296676
http://dx.doi.org/10.1007/s10719-016-9681-3

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