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Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model
We hypothesize that diabetes-induced impaired collateral formation after a hindlimb ligation in rats is in part caused by intracellular glycation and that overexpression of glyoxalase-I (GLO-I), i.e. the major detoxifying enzyme for advanced-glycation-endproduct (AGE) precursors, can prevent this. W...
Autores principales: | Brouwers, Olaf, Yu, Liang, Niessen, Petra, Slenter, Jos, Jaspers, Karolien, Wagenaar, Allard, Post, Mark, Miyata, Toshio, Backes, Walter, Stehouwer, Coen, Huijberts, Maya, Schalkwijk, Casper |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975762/ https://www.ncbi.nlm.nih.gov/pubmed/27296676 http://dx.doi.org/10.1007/s10719-016-9681-3 |
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