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Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity

Recently, medium-chain triglycerides (MCTs) containing a large fraction of lauric acid (LA) (C12)—about 30%—have been introduced commercially for use in salad oils and in cooking applications. As compared to the long-chain fatty acids found in other cooking oils, the medium-chain fats in MCTs are fa...

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Autores principales: McCarty, Mark F, DiNicolantonio, James J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975867/
https://www.ncbi.nlm.nih.gov/pubmed/27547436
http://dx.doi.org/10.1136/openhrt-2016-000467
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author McCarty, Mark F
DiNicolantonio, James J
author_facet McCarty, Mark F
DiNicolantonio, James J
author_sort McCarty, Mark F
collection PubMed
description Recently, medium-chain triglycerides (MCTs) containing a large fraction of lauric acid (LA) (C12)—about 30%—have been introduced commercially for use in salad oils and in cooking applications. As compared to the long-chain fatty acids found in other cooking oils, the medium-chain fats in MCTs are far less likely to be stored in adipose tissue, do not give rise to ‘ectopic fat’ metabolites that promote insulin resistance and inflammation, and may be less likely to activate macrophages. When ingested, medium-chain fatty acids are rapidly oxidised in hepatic mitochondria; the resulting glut of acetyl-coenzyme A drives ketone body production and also provokes a thermogenic response. Hence, studies in animals and humans indicate that MCT ingestion is less obesogenic than comparable intakes of longer chain oils. Although LA tends to raise serum cholesterol, it has a more substantial impact on high density lipoprotein (HDL) than low density lipoprotein (LDL) in this regard, such that the ratio of total cholesterol to HDL cholesterol decreases. LA constitutes about 50% of the fatty acid content of coconut oil; south Asian and Oceanic societies which use coconut oil as their primary source of dietary fat tend to be at low cardiovascular risk. Since ketone bodies can exert neuroprotective effects, the moderate ketosis induced by regular MCT ingestion may have neuroprotective potential. As compared to traditional MCTs featuring C6–C10, laurate-rich MCTs are more feasible for use in moderate-temperature frying and tend to produce a lower but more sustained pattern of blood ketone elevation owing to the more gradual hepatic oxidation of ingested laurate.
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spelling pubmed-49758672016-08-19 Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity McCarty, Mark F DiNicolantonio, James J Open Heart Cardiac Risk Factors and Prevention Recently, medium-chain triglycerides (MCTs) containing a large fraction of lauric acid (LA) (C12)—about 30%—have been introduced commercially for use in salad oils and in cooking applications. As compared to the long-chain fatty acids found in other cooking oils, the medium-chain fats in MCTs are far less likely to be stored in adipose tissue, do not give rise to ‘ectopic fat’ metabolites that promote insulin resistance and inflammation, and may be less likely to activate macrophages. When ingested, medium-chain fatty acids are rapidly oxidised in hepatic mitochondria; the resulting glut of acetyl-coenzyme A drives ketone body production and also provokes a thermogenic response. Hence, studies in animals and humans indicate that MCT ingestion is less obesogenic than comparable intakes of longer chain oils. Although LA tends to raise serum cholesterol, it has a more substantial impact on high density lipoprotein (HDL) than low density lipoprotein (LDL) in this regard, such that the ratio of total cholesterol to HDL cholesterol decreases. LA constitutes about 50% of the fatty acid content of coconut oil; south Asian and Oceanic societies which use coconut oil as their primary source of dietary fat tend to be at low cardiovascular risk. Since ketone bodies can exert neuroprotective effects, the moderate ketosis induced by regular MCT ingestion may have neuroprotective potential. As compared to traditional MCTs featuring C6–C10, laurate-rich MCTs are more feasible for use in moderate-temperature frying and tend to produce a lower but more sustained pattern of blood ketone elevation owing to the more gradual hepatic oxidation of ingested laurate. BMJ Publishing Group 2016-07-27 /pmc/articles/PMC4975867/ /pubmed/27547436 http://dx.doi.org/10.1136/openhrt-2016-000467 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Cardiac Risk Factors and Prevention
McCarty, Mark F
DiNicolantonio, James J
Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity
title Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity
title_full Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity
title_fullStr Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity
title_full_unstemmed Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity
title_short Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity
title_sort lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity
topic Cardiac Risk Factors and Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975867/
https://www.ncbi.nlm.nih.gov/pubmed/27547436
http://dx.doi.org/10.1136/openhrt-2016-000467
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