Hedgehog Signalling in the Embryonic Mouse Thymus

T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathw...

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Autores principales: Barbarulo, Alessandro, Lau, Ching-In, Mengrelis, Konstantinos, Ross, Susan, Solanki, Anisha, Saldaña, José Ignacio, Crompton, Tessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975939/
https://www.ncbi.nlm.nih.gov/pubmed/27504268
http://dx.doi.org/10.3390/jdb4030022
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author Barbarulo, Alessandro
Lau, Ching-In
Mengrelis, Konstantinos
Ross, Susan
Solanki, Anisha
Saldaña, José Ignacio
Crompton, Tessa
author_facet Barbarulo, Alessandro
Lau, Ching-In
Mengrelis, Konstantinos
Ross, Susan
Solanki, Anisha
Saldaña, José Ignacio
Crompton, Tessa
author_sort Barbarulo, Alessandro
collection PubMed
description T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation.
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spelling pubmed-49759392016-08-06 Hedgehog Signalling in the Embryonic Mouse Thymus Barbarulo, Alessandro Lau, Ching-In Mengrelis, Konstantinos Ross, Susan Solanki, Anisha Saldaña, José Ignacio Crompton, Tessa J Dev Biol Review T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte–TEC cross-talk in the embryonic mouse thymus during the last week of gestation. MDPI 2016-07-16 /pmc/articles/PMC4975939/ /pubmed/27504268 http://dx.doi.org/10.3390/jdb4030022 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Barbarulo, Alessandro
Lau, Ching-In
Mengrelis, Konstantinos
Ross, Susan
Solanki, Anisha
Saldaña, José Ignacio
Crompton, Tessa
Hedgehog Signalling in the Embryonic Mouse Thymus
title Hedgehog Signalling in the Embryonic Mouse Thymus
title_full Hedgehog Signalling in the Embryonic Mouse Thymus
title_fullStr Hedgehog Signalling in the Embryonic Mouse Thymus
title_full_unstemmed Hedgehog Signalling in the Embryonic Mouse Thymus
title_short Hedgehog Signalling in the Embryonic Mouse Thymus
title_sort hedgehog signalling in the embryonic mouse thymus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975939/
https://www.ncbi.nlm.nih.gov/pubmed/27504268
http://dx.doi.org/10.3390/jdb4030022
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