PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis

Many types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates the cell cycle, but other substrates of Cdc25A and their relevant cellular functions have yet to be identified. We demonstrate here that EGFR activation...

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Detalles Bibliográficos
Autores principales: Liang, Ji, Cao, Ruixiu, Zhang, Yajuan, Xia, Yan, Zheng, Yanhua, Li, Xinjian, Wang, Liwei, Yang, Weiwei, Lu, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976202/
https://www.ncbi.nlm.nih.gov/pubmed/27485204
http://dx.doi.org/10.1038/ncomms12431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976202/
https://www.ncbi.nlm.nih.gov/pubmed/27485204
http://dx.doi.org/10.1038/ncomms12431

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