Intrinsic limits to gene regulation by global crosstalk

Gene regulation relies on the specificity of transcription factor (TF)–DNA interactions. Limited specificity may lead to crosstalk: a regulatory state in which a gene is either incorrectly activated due to noncognate TF–DNA interactions or remains erroneously inactive. As each TF can have numerous i...

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Detalles Bibliográficos
Autores principales: Friedlander, Tamar, Prizak, Roshan, Guet, Călin C., Barton, Nicholas H., Tkačik, Gašper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976215/
https://www.ncbi.nlm.nih.gov/pubmed/27489144
http://dx.doi.org/10.1038/ncomms12307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976215/
https://www.ncbi.nlm.nih.gov/pubmed/27489144
http://dx.doi.org/10.1038/ncomms12307

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